Age-related changes in retinal functional topography.

PURPOSE To perform a detailed topographical analysis of functional age-related changes over the retina. METHODS Fifty-nine normal phakic subjects aged 10 to 69 years were divided into six groups, according to decade of age. mfERG traces were recorded from the central 60 degrees of the retina, with a resolution of 61 and 103 scaled hexagons. Group medians of peak amplitude and latency of the first- and second-order (first slice) responses were used to generate 3-D topographical maps. RESULTS With age, there was a continuous loss of amplitude and delay of implicit time of the first- and the second-order response components, but the topography of the loss was not uniform across the retina. Trend analyses on ring group data showed a significant decrease in amplitude of first- and second-order responses although the age relationship of second-order responses was more complex. The loss of first-order kernel amplitude was generally accompanied by a rise in implicit time. Second-order kernel latencies showed no uniform alteration with age. CONCLUSIONS Consistent with previous work, a steady loss of amplitude and increase of implicit time was observed with age. The topographical 3-D data, however, reveal age-related functional alterations in the retina beyond those found in ring averages, suggesting that these are masked by the standard analysis. Thus, the choice of physiologically coherent regions of interest may increase the sensitivity of detecting age-related change in multifocal analysis of retinal function.